化工社化工社 化学情報印刷レポート · 研究参考用
Aniline → 2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl- | HCID 84657 | — |
反応手順
2-fluoronitrobenzene was treated with aniline in the prescence of K2CO3 in CH3CN and heated to reflux for 12 h. The solution is cooled, filtered and the solvent removed. The nitro group is reduced with catalytic hydrogenation and the diamine treated with CDI to give 1-phenyl-1,3-dihydro-benzoimidazol-2-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06506738B1 |
| 出典データセット | uspto-grants-2003_01 |
| ORD ID | ord-6ce79da2204742599c88902fe82d6331 |
| 出典メモ | uspto-grants-2003_01 |