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HRID1634023

反应详情

EQUATION

反应方程式

HRID 1634023 的结构方程式

REACTANTS

反应物

3
结构：Nc1ccccc1
HCID6115

Aniline

C6H7N

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：O=[N+]([O-])c1ccccc1F
HCID73895

Benzene, 1-fluoro-2-nitro-

C6H4FNO2

PRODUCTS

生成物

1
结构：O=c1[nH]c2ccccc2n1-c1ccccc1
HCID84657

2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl-

C13H10N2O

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

2-fluoronitrobenzene was treated with aniline in the prescence of K2CO3 in CH3CN and heated to reflux for 12 h. The solution is cooled, filtered and the solvent removed. The nitro group is reduced with catalytic hydrogenation and the diamine treated with CDI to give 1-phenyl-1,3-dihydro-benzoimidazol-2-one.

WORKUP

后处理

  1. temperatureheated
  2. temperatureto reflux for 12 h
  3. temperatureThe solution is cooled
  4. filtrationfiltered
  5. customthe solvent removed
  6. additionthe diamine treated with CDI