Tetrahydrofuran → 2,6-Dimethylbenzaldehyde

HRID 1634114

反応式

HRID 1634114 の反応式
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[C:4]#N.CC(C[AlH]CC(C)C)C.C1C[O:23]CC1>>[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[CH:4]=[O:23]

参加物

4

反応物 3

HCID 8028TetrahydrofuranHCID 14487Diisobutylaluminum hydrideHCID 810572,6-Dimethylbenzonitrile

生成物 1

HCID 5838412,6-Dimethylbenzaldehyde

実験手順

To a stirred solution of 2,6-dimethylbenzonitrile (1 g, 7.6 mmol) in THF (15 mL) under argon at 0° C. a solution of DIBAL (1 M in THF, 8 mL, 8 mmol) was added dropwise over 5 minutes. After 3 hr at 0° C., the reaction mixture was brought to room temperature and stirred overnight. The reaction was quenched with 5% sulfuric acid at 0° C., extracted with ether, washed with brine and dried (MgSO4). Concentration provided 2,6-dimethylbenzaldehyde (0.9 g) which was used without further purification.

後処理

  1. customwas brought to room temperature
  2. customThe reaction was quenched with 5% sulfuric acid at 0° C.
  3. extractionextracted with ether
  4. washwashed with brine
  5. dry with materialdried (MgSO4)
  6. concentrationConcentration

出典と根拠

ORDレコード
ord-49388930f4a64977b8c3b4c756ea2757
出典データセット
uspto-grants-2003_01
特許番号
US06506747B1

関連ノート

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