Sodium Hydroxide → 3-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-2,2-dimethyl-propionic acid
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([CH3:16])([CH3:15])[C:11]([O:13]C)=[O:12])=[CH:5][C:4]=1[C:17](=[O:30])[NH:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([CH3:16])([CH3:15])[C:11]([OH:13])=[O:12])=[CH:5][C:4]=1[C:17](=[O:30])[NH:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=1参加物
4
実験手順
Using methyl 3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]-2,2-dimethylpropanoate (300 mg, 0.708 mmol; Example 47), ethanol (5 ml) and 10% aqueous solution of sodium hydroxide (2 ml) and conducting the procedure similar to Example 22, 206 mg (90%) of the title compound were obtained as colorless crystals.