1,6-dimethyl-2-(1-methoxyethyl)-3-benzyloxy-pyridin-4(1H)-one hydrochloride → 1,6-Dimethyl-2-(1-methoxyethyl)-3-hydroxy-pyridin-4(1H)-one hydrochloride
反応式
[ClH:1].CN1C(C)=CC(=O)C(O)=C1COC.Cl.[CH3:16][N:17]1[C:22]([CH3:23])=[CH:21][C:20](=[O:24])[C:19]([O:25]CC2C=CC=CC=2)=[C:18]1[CH:33]([O:35][CH3:36])[CH3:34]>[Pd]>[ClH:1].[CH3:16][N:17]1[C:22]([CH3:23])=[CH:21][C:20](=[O:24])[C:19]([OH:25])=[C:18]1[CH:33]([O:35][CH3:36])[CH3:34]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
In an analogous hydrogenation procedure in the preparation of 1,6-dimethyl-2-methoxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride using 1,6-dimethyl-2-(1-methoxyethyl)-3-benzyloxy-pyridin-4(1H)-one hydrochloride (1.62 g, 5 mmol) and 5% Pd/C catalyst (0.35 g) yield the title compound 1.06 g (90%) after recrystallisation from methanol/diethyl ether, as a white crystalline solid. m.p. 205-207° C.