1-Ethyl-2-methoxymethyl-3-benzyloxy-6-methyl-pyridin-4(1H)-one hydrochloride → 1-Ethyl-2-methoxymethyl-3-hydroxy-6-methyl-pyridin-4(1H)-one hydrochloride

HRID 1634615ノート

反応式

HRID 1634615 の反応式
[ClH:1].CN1C(C)=CC(=O)C(O)=C1COC.Cl.[CH2:16]([N:18]1[C:23]([CH3:24])=[CH:22][C:21](=[O:25])[C:20]([O:26]CC2C=CC=CC=2)=[C:19]1[CH2:34][O:35][CH3:36])[CH3:17]>[Pd]>[ClH:1].[CH2:16]([N:18]1[C:23]([CH3:24])=[CH:22][C:21](=[O:25])[C:20]([OH:26])=[C:19]1[CH2:34][O:35][CH3:36])[CH3:17]

参加物

4

反応物 2

HCID 186787941-Ethyl-2-methoxymethyl-3-benzyloxy-6-methyl-pyridin-4(1H)-one hydrochlorideHCID 186788241,6-Dimethyl-2-methoxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride

生成物 1

HCID 186787921-Ethyl-2-methoxymethyl-3-hydroxy-6-methyl-pyridin-4(1H)-one hydrochloride収率 83%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

In an analogous hydrogenation procedure in the preparation of 1,6-dimethyl-2-methoxymethyl-3-hydroxy-pyridin-4(1H)-one hydrochloride using 1-ethyl-2-methoxymethyl-3-benzyloxy-6-methyl-pyridin-4(1H)-one hydrochloride (1.3 g, 4 mmol) and 5% Pd/C catalyst (0.3 g) yield the title compound 0.78 g (83%) after recrystallisation from methanol/diethyl ether, as a white crystalline solid. m.p. 174-176° C.

出典と根拠

ORDレコード
ord-fdb9d44fba2846b89931d6fd54cb3732
出典データセット
uspto-grants-2003_01
特許番号
US06506911B2

反応ノート

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