2-Methoxy-6-nitrophenylacetic acid → 4-Methoxy-2-indolinone
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[C:4]=1[CH2:12][C:13]([OH:15])=O>[Pd].C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:4]=1[CH2:12][C:13](=[O:15])[NH:9]2参加物
4
実験手順
A mixture of 2-methoxy-6-nitrophenylacetic acid (31 g, 150 mmol), and 3.0 g of 10% palladium on carbon in 200 mL of glacial acetic acid was stirred under an atmosphere of H2 gas until uptake ceased. The catalyst was filtered and the solvent evaporated in vacuo. The crude product was crystallized from methanol to give 9.0 g of the title compound.
後処理
- filtrationThe catalyst was filtered
- customthe solvent evaporated in vacuo
- customThe crude product was crystallized from methanol
出典と根拠
- ORDレコード
- ord-70dd1cf5d8894f15bdad729350d42a10
- 出典データセット
- uspto-grants-2003_01
- 特許番号
- US06506901B2
反応ノート
読み込み中…