4-Piperidinecarboxamide → HCID 18678413、化合物
反応式
[NH:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1.I[CH2:11][CH2:12][CH3:13].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:11]([N:1]1[CH2:9][CH2:8][CH:4]([C:5]([NH2:7])=[O:6])[CH2:3][CH2:2]1)[CH2:12][CH3:13]参加物
5
実験手順
A solution of isonipecotamide (2.0 g, 15.6 mmol), 1-iodopropane (1.52 mL, 15.6 mmol), and potassium carbonate (2.15 g, 15.6 mmol) was heated at reflux in 100 mL of 2-butanone. The solids were filtered and the filtrate concentrated in vacuo to give crude product. Purification by flash chromatography (CH2Cl2—CH3OH, 12:1 ) afforded 1.25 9 of the product as an off-white solid.
後処理
- filtrationThe solids were filtered
- concentrationthe filtrate concentrated in vacuo
- customto give crude product
- customPurification by flash chromatography (CH2Cl2—CH3OH, 12:1 )
出典と根拠
- ORDレコード
- ord-fb5664b344544ed0952d240deb524651
- 出典データセット
- uspto-grants-2003_01
- 特許番号
- US06506901B2
反応ノート
読み込み中…