Chlorosulfonic acid → HCID 18173760、化合物

HRID 1634798ノート

反応式

HRID 1634798 の反応式
[CH2:1]([NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[Cl:19][S:20](O)(=[O:22])=[O:21]>>[CH2:1]([NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([S:20]([Cl:19])(=[O:22])=[O:21])=[CH:15][CH:14]=1)=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

3

反応物 2

HCID 24638Chlorosulfonic acidHCID 3297718HCID 3297718、化合物

生成物 1

HCID 18173760HCID 18173760、化合物収率 15.3%

実験手順

N-octyl-N′-phenylurea (10 g, 215 mmol) was dissolved in chlorosulfonic acid 925 g and stirred for 14 hours at ambient temperature. The reaction was poured into ice and extracted with ethyl acetate. The organic layer was washed with cold, dilute aqueous sodium bicarbonate, then dried (Na2SO4). The solvent was evaporated in vacuo to give the product as a white solid (11.46 g, 33 mmol).

後処理

  1. additionThe reaction was poured into ice
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with cold, dilute aqueous sodium bicarbonate
  4. dry with materialdried (Na2SO4)
  5. customThe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-4a383129635d43a2aba73c5f89fba188
出典データセット
uspto-grants-2003_01
特許番号
US06506901B2

反応ノート

読み込み中…