Diisopropylethylamine → HCID 70000670、化合物

反応式

[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[CH3:16][N:17]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=2)[C:18]1=[O:32].C(N(C(C)C)CC)(C)C>>[C:1]([O:5][C:6](=[O:15])[NH:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([S:28]([C:25]2[CH:26]=[CH:27][C:22]([N:19]3[CH2:20][CH2:21][N:17]([CH3:16])[C:18]3=[O:32])=[CH:23][CH:24]=2)(=[O:30])=[O:29])[CH2:13][CH2:14]1)([CH3:4])([CH3:2])[CH3:3]

参加物

反応物 3

HCID 81531Diisopropylethylamine

HCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamate

HCID 186784164-(3-Methyl-2-oxo-1-imidazolidinyl)benzenesulfonyl chloride

生成物 1

HCID 70000670HCID 70000670、化合物収率 65%

実験手順

Prepared according to the procedure used for example 46 (Step A, part 1) from piperidin-4-ylmethyl-carbamic acid t-butyl ester (1.09 g, 5.1 mmol), 4-(3-methyl-2-oxo-imidazolidin-1-yl)-benzenesulfonyl chloride (1.4 g, 5.1 mmol) and 0.89 mL of diisopropylethyl amine to give 1.5 g of the title compound

後処理

customPrepared

出典と根拠

ORDレコード: ord-c055468cd1b64ddea4c7dcca4fb8bf2c
出典データセット: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06506901B2

反応ノート

読み込み中…