Water → 2-Hydroxy-3-(N,N-dibutylcarbamoylmethoxy)-3,3-diphenylpropionic acid

HRID 1635079ノート

反応式

HRID 1635079 の反応式
[OH:1][CH:2]([C:7]([O:20][CH2:21][C:22](=[O:32])[N:23]([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:24][CH2:25][CH2:26][CH3:27])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([O:5]C)=[O:4].[OH-].[Na+].O>O1CCOCC1>[OH:1][CH:2]([C:7]([O:20][CH2:21][C:22](=[O:32])[N:23]([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:24][CH2:25][CH2:26][CH3:27])([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 18675624methyl 2-hydroxy-3-(N,N-dibutylcarbamoylmethoxy)-3,3-diphenylpropionate

生成物 1

HCID 154275402-Hydroxy-3-(N,N-dibutylcarbamoylmethoxy)-3,3-diphenylpropionic acid収率 80%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

1.42 g of methyl 2-hydroxy-3-(N,N-dibutylcarbamoylmethoxy)-3,3-diphenylpropionate were dissolved in 10 ml of dioxane and 4.8 ml of 1N sodium hydroxide solution and stirred at room temperature for 3 hours. Water was then added to the mixture, and the aqueous phase was extracted with ether. The aqueous phase was acidified with hydrochloric acid and extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate. After removal of the solvent by distillation, 1.1 g of oil were isolated and were immediately employed further.

後処理

  1. extractionthe aqueous phase was extracted with ether
  2. extractionextracted with ethyl acetate
  3. dry with materialthe organic phase was dried over magnesium sulfate
  4. customAfter removal of the solvent
  5. distillationby distillation

出典と根拠

ORDレコード
ord-8a9e66e93f4b4cc993971a02d9a70cb8
出典データセット
uspto-grants-2003_01
特許番号
US06509341B1

反応ノート

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