Tetrahydrofuran → Gamma-secretase modulators

反応式

O.[OH-].[Li+].O1CCCC1.C(OP([CH:17]1[C:26](=[O:27])[N:25]2[C@H:20]([CH2:21][O:22][CH2:23][C@H:24]2[C:28]2[CH:33]=[C:32]([F:34])[C:31]([F:35])=[C:30]([F:36])[CH:29]=2)[CH2:19][CH2:18]1)(=O)OCC)C.[CH3:37][O:38][C:39]1[CH:40]=[C:41]([CH:44]=[CH:45][C:46]=1[N:47]1[CH:51]=[C:50]([CH3:52])[N:49]=[CH:48]1)[CH:42]=O>O.C(OCC)(=O)C.C(O)C>[CH3:37][O:38][C:39]1[CH:40]=[C:41]([CH:44]=[CH:45][C:46]=1[N:47]1[CH:51]=[C:50]([CH3:52])[N:49]=[CH:48]1)/[CH:42]=[C:17]1\[CH2:18][CH2:19][C@@H:20]2[N:25]([C:26]\1=[O:27])[C@H:24]([C:28]1[CH:29]=[C:30]([F:36])[C:31]([F:35])=[C:32]([F:34])[CH:33]=1)[CH2:23][O:22][CH2:21]2