Thionyl Chloride → HCID 12011185、化合物

HRID 1635575ノート

反応式

HRID 1635575 の反応式
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16]O>>[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16][Cl:3]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 12011184HCID 12011184、化合物

生成物 1

HCID 12011185HCID 12011185、化合物

反応条件

温度
50 °C

実験手順

To 3 ml of thionyl chloride is added 2.39 g (9.5 mmol) of 1-(2′-chlorobenzyl)-4,5-dimethyl-2-hydroxymethyl-imidazole. The mixture is heated at 50° C. for about 5 min., and the thionyl chloride is evaporated in vacuo. The residue is dissolved in 10 ml of dichloromethane, then evaporated in vacuo. This is repeated twice to give 1-(2′-chlorobenzyl)-4,5-dimethyl-2-chloromethylimidazole as a cream colored foam which is used in next step without further purification.

後処理

  1. customthe thionyl chloride is evaporated in vacuo
  2. dissolutionThe residue is dissolved in 10 ml of dichloromethane
  3. customevaporated in vacuo

出典と根拠

ORDレコード
ord-6e8114d43c824ef5bd49c1e52ae14c53
出典データセット
uspto-grants-2003_01
特許番号
US06509366B2

反応ノート

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