Thionyl Chloride → 6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-carbonyl chloride
反応式
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[CH:11][C:10]([C:13]([OH:15])=O)=[CH:9][CH:8]=2)[CH:4]=[N:3]1.S(Cl)([Cl:18])=O>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[N:12]=[CH:11][C:10]([C:13]([Cl:18])=[O:15])=[CH:9][CH:8]=2)[CH:4]=[N:3]1参加物
3
実験手順
A suspension of 6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-carboxylic Acid (0.48 g) in thionyl chloride (5.0 ml) was stirred at room temperature for 2 hours. The volatile material was removed under reduced pressure to afford 6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-carbonyl chloride as a solid, which was utilized without further purification.
後処理
- customThe volatile material was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-5ac90fce5a324bf4a23e1906c98d225b
- 出典データセット
- uspto-grants-2003_01
- 特許番号
- US06511974B1
反応ノート
読み込み中…