Nitric Acid → 2-Chloro-6-fluoro-3-nitrobenzeneacetic acid

HRID 1635923

反応式

HRID 1635923 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10]([OH:12])=[O:11].S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>>[Cl:1][C:2]1[C:7]([N+:18]([O-:20])=[O:19])=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10]([OH:12])=[O:11]

参加物

4

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 1234642-Chloro-6-fluorophenylacetic acid

生成物 1

HCID 696933382-Chloro-6-fluoro-3-nitrobenzeneacetic acid収率 78%

実験手順

1.89 g of 2-chloro-6-fluoro-phenylacetic acid was suspended in 20 ml of concentrated nitric acid. After the addition of 10 ml of concentrated sulfuric acid, the resulting mixture was heated under reflux for 3.5 hours. After the reaction mixture was poured into ice water, the resulting precipitate was collected by filtration, washed with a small amount of purified water, and then dried. Thus, 1.83 g (78% yield) of the title compound was obtained as a white powder.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 3.5 hours
  3. filtrationthe resulting precipitate was collected by filtration
  4. washwashed with a small amount of purified water
  5. customdried

出典と根拠

ORDレコード
ord-62993e7f5fc24a7da8ff2c1508456f84
出典データセット
uspto-grants-2003_01
特許番号
US06511997B1

関連ノート

読み込み中…