HCID 86586541、化合物 → HCID 10156794、化合物

HRID 1636065ノート

反応式

HRID 1636065 の反応式
C([O:8][NH:9][C:10](=[O:35])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:34]=[CH:33][C:22]2[O:23][CH2:24][C:25]3[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=3[C:27](=[O:28])[C:21]=2[CH:20]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][NH:9][C:10](=[O:35])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:34]=[CH:33][C:22]2[O:23][CH2:24][C:25]3[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=3[C:27](=[O:28])[C:21]=2[CH:20]=1

参加物

4

反応物 1

HCID 86586541HCID 86586541、化合物

生成物 1

HCID 10156794HCID 10156794、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

400 mg (0.845 mmol) 8-(11-Oxo-6,11-dihydro-dibenzo[b,e]oxepin-2 yloxy)-octanoic acid benzyloxyamide in 50 ml methanol was hydrogenated in the presence of palladium on calcium carbonate at ambient temperature and pressure. The catalyst was removed by filtration and the solvent was evaporated. The residue was purified by column chromatography (methanol/water 75:25). There was thus obtained 90 mg (28%) of the title compound as an amorphous solid. MS: 382 (M−H+); 384 (M+H+).

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated
  3. customThe residue was purified by column chromatography (methanol/water 75:25)

出典と根拠

ORDレコード
ord-9450982f2fc1429b88f10c77f65d4f73
出典データセット
uspto-grants-2003_01
特許番号
US06512123B2

反応ノート

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