2,6-Dibromopyridine → 2-Bromo-6-ethoxypyridine

HRID 1636185ノート

反応式

HRID 1636185 の反応式
[O-:1][CH2:2][CH3:3].[Na+].Br[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Br:12])[N:7]=1>C1(C)C=CC=CC=1.O>[Br:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([O:1][CH2:2][CH3:3])[N:7]=1

参加物

5

反応物 2

HCID 122742,6-DibromopyridineHCID 2723922Sodium ethoxide

生成物 1

HCID 12010182-Bromo-6-ethoxypyridine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

Sodium ethoxide (1.5 g, 63 mmol sodium, in ethanol (30 ml)) was added to 2,6-dibromopyridine (15 g, 63 mmol) in toluene (150 ml) at ambient temperature under nitrogen, and the reaction heated under reflux for 5 hours. The cooled mixture was diluted with water (100 ml), and extracted with ethyl acetate (2×100 ml). The combined organic extracts were dried (Na2SO4), filtered and evaporated in vacuo. The residue was purified by column chromatography on silica gel using pentane/ethyl acetate (100:0 to 95:5) as eluant to give the title compound as a yellow oil, (quantitative).

後処理

  1. temperaturethe reaction heated
  2. temperatureunder reflux for 5 hours
  3. extractionextracted with ethyl acetate (2×100 ml)
  4. dry with materialThe combined organic extracts were dried (Na2SO4)
  5. filtrationfiltered
  6. customevaporated in vacuo
  7. customThe residue was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-b91aec63491f4d8699e97413d2b70208
出典データセット
uspto-grants-2003_01
特許番号
US06511993B1

反応ノート

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