Acetyl chloride → HCID 54052838、化合物

HRID 1636308ノート

反応式

HRID 1636308 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[N:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]=[N:12][N:13]2[CH:17]=[N:16][NH:15][C:14]2=[O:18])[CH:6]=1>N1C=CC=CC=1>[C:1]([N:15]1[C:14](=[O:18])[N:13]([N:12]=[CH:11][C:7]2[CH:6]=[N:5][CH:10]=[CH:9][CH:8]=2)[CH:17]=[N:16]1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 54560653HCID 54560653、化合物

生成物 1

HCID 54052838HCID 54052838、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2.4 g of acetyl chloride are added to a suspension of 3.8 g of 4-(pyridin-3-ylmethyleneamino)-1,2,4-triazol-3-one in 50 ml of pyridine. The resulting solution is stirred for 14 hours at 20° and then concentrated by evaporation. Water is added to the residue and extraction is carried out with chloroform. The organic phase is concentrated by evaporation and the residue is stirred with ether. The crystals are filtered off with suction and then dried under a high vacuum. 4 g of the title compound having a melting point of 164-166° are thus obtained.

後処理

  1. concentrationconcentrated by evaporation
  2. additionWater is added to the residue and extraction
  3. concentrationThe organic phase is concentrated by evaporation
  4. stirringthe residue is stirred with ether
  5. filtrationThe crystals are filtered off with suction
  6. customdried under a high vacuum
  7. customare thus obtained

出典と根拠

ORDレコード
ord-8ba73ba7b69b4cc1ad066b02c4331657
出典データセット
uspto-grants-2000_03
特許番号
US06034083

反応ノート

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