Iodine chloride → 2-(4'-Amino-3'-iodophenyl)benzoxazole

HRID 1636555

反応式

HRID 1636555 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[I:17]Cl>C(O)(=O)C>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][C:7]=1[I:17]

参加物

4

反応物 2

HCID 24640Iodine chlorideHCID 88733Benzenamine, 4-(2-benzoxazolyl)-

生成物 1

HCID 106645602-(4'-Amino-3'-iodophenyl)benzoxazole収率 65.8%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2-(4'-Aminophenyl)benzoxazole (0.14 g, 1.9 mmol) was treated with iodine monochloride (0.37 g, 2.23 mmol) in acetic acid according to the above-described general procedure for iodination. Crude product was purified by flash chromatography on silica gel using ethyl acetate-hexane (1:2) as eluent to give a brown powder (0.42 g, 65.7%), m.p. 188.0-191.2° C.

後処理

  1. customCrude product was purified by flash chromatography on silica gel

出典と根拠

ORDレコード
ord-a07fadc62b394afeb50f1cdbfe96ed79
出典データセット
uspto-grants-2000_03
特許番号
US06034246

関連ノート

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