Sodium Hydroxide → HCID 492712、化合物
反応式
[CH:1]1[C:7]([NH2:8])=[N:6][C:4](=[S:5])[NH:3][C:2]=1[Cl:9].[OH-].[Na+].[Cl:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([CH2:19]Cl)[CH:14]=1>C(O)C>[CH:18]1[C:13]([Cl:12])=[CH:14][C:15]([CH2:19][S:5][C:4]2[N:3]=[C:2]([Cl:9])[CH:1]=[C:7]([NH2:8])[N:6]=2)=[N:16][CH:17]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
4-Amino-6-chloro-2-thio-pyrimidine (Cpd #110; 614 mg, 2.38 mmol) in ethanol (1.5 ml) is treated with 3.25 M NaOH (1.47 ml, 4.8 mmol) and the mixture is warmed to 50° C. 4-chloro-2-chloromethyl pyridine is added and the solution is stirred warm for 1 hour. The reaction mixture is cooled and concentrated in vacuo, and the resultant solid is filtered and washed with water followed by cold ethanol, mp 195° C.
後処理
- temperaturewarm for 1 hour
- temperatureThe reaction mixture is cooled
- concentrationconcentrated in vacuo
- filtrationthe resultant solid is filtered
- washwashed with water
出典と根拠
- ORDレコード
- ord-a2d3dc2863e74ac4971686399f3a0c2d
- 出典データセット
- uspto-grants-2000_03
- 特許番号
- US06043248
反応ノート
読み込み中…