Thionyl Chloride → 2-Chloro-3-methoxy-4-vinyl-6-(1-chloroethyl)-pyridine
反応式
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH:10]=[CH2:11])[CH:5]=[C:4]([CH:12](O)[CH3:13])[N:3]=1.S(Cl)([Cl:17])=O>C(Cl)Cl>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH:10]=[CH2:11])[CH:5]=[C:4]([CH:12]([Cl:17])[CH3:13])[N:3]=1参加物
4
実験手順
A solution of 2-chloro-3-methoxy-4-vinyl-6-(1-hydroxyethyl)-pyridine (446 mg, 2.09 mmol) in 10 mL of methylene chloride at 0° C. is treated with thionyl chloride (0.227 mL, 3.13 mmol) and stirred at room temperature for 1 h. The reaction is quenched with 15 mL of saturated sodium bicarbonate. The aqueous layer is extracted with 3×10 mL of methylene chloride. The combined organics are dried over potassium carbonate and concentrated in vacuo to provide 447 mg (92%) of 2-chloro-3-methoxy-4-vinyl-6-(1-chloroethyl)-pyridine.
後処理
- customThe reaction is quenched with 15 mL of saturated sodium bicarbonate
- extractionThe aqueous layer is extracted with 3×10 mL of methylene chloride
- dry with materialThe combined organics are dried over potassium carbonate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-1d551c35b1cc4323b8710edd95fbe3ac
- 出典データセット
- uspto-grants-2000_03
- 特許番号
- US06043248
反応ノート
読み込み中…