化工社化工社 化学情報印刷レポート · 研究参考用
4-Nitrobenzaldehyde → 5-[(4-Aminophenyl)methylidene]-1,3-thiazolidine-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzaldehyde | HCID 541 | — |
| 反応物 | Thiazolidinedione | HCID 5437 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 5-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione | HCID 2768264 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-[(4-Aminophenyl)methylidene]-1,3-thiazolidine-2,4-dione | HCID 54182543 | — |
反応手順
Prepared by catalytic hydrogenation of 5-(4-nitro-benzylidene)-thiazolidin-2,4-dione [melting point: 265-270° C.; obtained by heating 4-nitro-benzaldehyde and 2 equivalents of thiazolidin-2,4-dione in the presence of piperidine in toluene using a water separator] in glacial acetic acid on palladium/charcoal (10%) (50° C., 3.5 bar, 0.5 hours).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06043254 |
| 出典データセット | uspto-grants-2000_03 |
| ORD ID | ord-55b5b5f99ad647a0932ca3ac0aa578f8 |
| 出典メモ | uspto-grants-2000_03 |