Methyl Isocyanate → HCID 14601660、化合物

HRID 1638288ノート

反応式

HRID 1638288 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16][CH2:15]3)=[O:13])[C:6]=2[CH:21]=1.[CH3:22][N:23]=[C:24]=[O:25]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:15][CH2:16][CH:17]([O:20][C:24](=[O:25])[NH:23][CH3:22])[CH2:18][CH2:19]3)=[O:13])[C:6]=2[CH:21]=1

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 3082453Hpr 611

生成物 1

HCID 14601660HCID 14601660、化合物収率 71.8%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
30 °C

実験手順

5-Chloro-3-(4-hydroxypiperidinocarbonylmethyl)benzothiazolin-2-one (3.2 g) was dissolved in dry pyridine (15 ml) and the solution was cooled. After methyl isocyanate (0.9 g) was dropwise added to the solution, the resultant was stirred for 15 hours at 30° C. Pyridine was evaporated off under vacuum from the reaction mixture and the residue was recrystallized from methanol to yield the title compound as colorless crystals (2.7 g). mp 202°-203° C.

後処理

  1. temperaturethe solution was cooled
  2. customPyridine was evaporated off under vacuum from the reaction mixture
  3. customthe residue was recrystallized from methanol

出典と根拠

ORDレコード
ord-971f1681d3e74e3b9c571b190f6cc604
出典データセット
uspto-grants-1989_11
特許番号
US04879301

反応ノート

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