Ethyl isocyanate → HCID 14601661、化合物

HRID 1638289ノート

反応式

HRID 1638289 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16][CH2:15]3)=[O:13])[C:6]=2[CH:21]=1.[CH2:22]([N:24]=[C:25]=[O:26])[CH3:23]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:15][CH2:16][CH:17]([O:20][C:25](=[O:26])[NH:24][CH2:22][CH3:23])[CH2:18][CH2:19]3)=[O:13])[C:6]=2[CH:21]=1

参加物

4

反応物 2

HCID 8022Ethyl isocyanateHCID 3082453Hpr 611

生成物 1

HCID 14601661HCID 14601661、化合物収率 77%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
50 °C

実験手順

5-Chloro-3-(4-hydroxypiperidinocarbonylmethyl)benzothiazolin-2-one (3.2 g) was dissolved in dry pyridine (15 ml) and the solution was cooled. After ethyl isocyanate (0.9 g) was dropwise added to the solution, the resultant was stirred for 10 hours at 50° C. Pyridine was evaporated off under vacuum from the reaction mixture and the residue was recrystallized from ethanol to yield the title compound as colorless crystals (3.0 g). mp 210°-211° C.

後処理

  1. temperaturethe solution was cooled
  2. customPyridine was evaporated off under vacuum from the reaction mixture
  3. customthe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-e9a7cdace81f4524b93ffcfcc41921c6
出典データセット
uspto-grants-1989_11
特許番号
US04879301

反応ノート

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