Triethylamine → 2-(Chloromethyl)-1,3,4-trifluorobenzene

HRID 1638679

反応式

HRID 1638679 の反応式
[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([F:11])[C:3]=1[CH2:4]O.S(Cl)([Cl:14])=O.C(N(CC)CC)C>ClCCl>[F:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[C:6]([F:11])[C:3]=1[CH2:4][Cl:14]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 1455002,3,6-Trifluorobenzyl alcohol

生成物 1

HCID 156318382-(Chloromethyl)-1,3,4-trifluorobenzene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 2,3,6-trifluorobenzyl alcohol (41 g) in dichloromethane (100 ml) is added dropwise a solution of thionyl chloride (50 ml) in dichloromethane (80 ml) under ice cooling with stirring, and the mixture is stirred at room temperature overnight. To the mixture is added triethylamine (10 ml), and the solvent is distilled off under reduced pressure to give 2,3,6-trifluorobenzyl chloride (28.6 g), as colorless oil, b.p. 63;L ° C. (13 mmHg).

後処理

  1. stirringthe mixture is stirred at room temperature overnight
  2. distillationthe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-51b1acbec42647b0b69e98c434852989
出典データセット
uspto-grants-1989_11
特許番号
US04880806

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