Water → 3-Ethyl-2,4,5-trifluoro-nitrobenzene

HRID 1638685ノート

反応式

HRID 1638685 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][CH3:11].[N+:12]([O-])([O-:14])=[O:13].[K+].O>S(=O)(=O)(O)O>[CH2:10]([C:3]1[C:4]([F:9])=[C:5]([N+:12]([O-:14])=[O:13])[CH:6]=[C:7]([F:8])[C:2]=1[F:1])[CH3:11]

参加物

5

反応物 3

HCID 962WaterHCID 24434Potassium NitrateHCID 148346762,3,6-Trifluoro-1-ethylbenzene

生成物 1

HCID 148346773-Ethyl-2,4,5-trifluoro-nitrobenzene収率 81.6%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

実験手順

2,3,6-Trifluoro-1-ethylbenzene (1.09 g) is dissolved in conc. sulfuric acid (5.5 ml), and thereto is added with stirring a mixture of potassium nitrate (0.83 g) in conc. sulfuric acid (4 ml) at room temperature, and the mixture is stirred at the same temperature for one hour. The reaction mixture is poured into cold water (100 ml) and is extracted with diethyl ether. The ether layer is washed with aqueous sodium chloride and dried over magnesium sulfate and then concentrated under reduced pressure to give 3-ethyl-2,4,5-trifluoro-nitrobenzene (1.14 g), as yellow oil.

後処理

  1. additionis added
  2. stirringthe mixture is stirred at the same temperature for one hour
  3. extractionis extracted with diethyl ether
  4. washThe ether layer is washed with aqueous sodium chloride
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-053e6eabbc1646e7a4afc026ba94d116
出典データセット
uspto-grants-1989_11
特許番号
US04880806

反応ノート

読み込み中…