Sodium Hydroxide → 3,4-Dihydro-6-(phenylmethoxy)-2-naphthalenecarboxylic acid

HRID 1638789ノート

反応式

HRID 1638789 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15](O)[CH:14]([C:20]([OH:22])=[O:21])[CH2:13][CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16]([CH:15]=[C:14]([C:20]([OH:22])=[O:21])[CH2:13][CH2:12]2)=[CH:17][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 19841196HCID 19841196、化合物

生成物 1

HCID 146761973,4-Dihydro-6-(phenylmethoxy)-2-naphthalenecarboxylic acid収率 79.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl ester of 6-benzyloxy-1-hydroxy-1,2,3,4-tetrahydro-2-naphthoic acid (0.6 g) is dissolved in methanol (50 ml). To the solution is added an aqueous solution (10 ml) of sodium hydroxide (2 g), and the mixture is left standing for 30 minutes at room temperature. The resultant is concentrated under reduced pressure. The concentrate is diluted with water (50 ml). The precipitating crystals are collected by filtration. This product is dissolved in a mixture of dioxane (50 ml) and concentrated hydrochloric acid (2 ml). The mixture is left standing for 5 minutes at 80° C. and then for 30 minutes at room temperature. The resultant is concentrated under reduced pressure. Water (50 ml) is added to the concentrate. The precipitating crystals are collected by filtration to give 7-benzyloxy-1,2-dihydro-3-naphthoic acid (0.45 g) as colorless crystals, followed by recrystallization from a mixture of methanol and acetone to afford colorless needles, m.p. 202°-205° C.

後処理

  1. waitthe mixture is left
  2. concentrationThe resultant is concentrated under reduced pressure
  3. additionThe concentrate is diluted with water (50 ml)
  4. filtrationThe precipitating crystals are collected by filtration
  5. dissolutionThis product is dissolved in a mixture of dioxane (50 ml) and concentrated hydrochloric acid (2 ml)
  6. waitThe mixture is left
  7. waitstanding for 5 minutes at 80° C.
  8. waitfor 30 minutes at room temperature
  9. concentrationThe resultant is concentrated under reduced pressure
  10. additionWater (50 ml) is added to the concentrate
  11. filtrationThe precipitating crystals are collected by filtration

出典と根拠

ORDレコード
ord-c2d425b448184586907ebbbe175e633e
出典データセット
uspto-grants-1989_11
特許番号
US04880809

反応ノート

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