Nitric Acid → 6-fluoro-5-nitro-2(3H)-benzoxazolone

HRID 1638832ノート

反応式

HRID 1638832 の反応式
[F:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[F:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 144573586-Fluoro-1,3-benzoxazol-2(3H)-one

生成物 1

HCID 137721116-fluoro-5-nitro-2(3H)-benzoxazolone収率 85%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 6-fluoro-2(3H)-benzoxazolone (1.0 g) in 80% aqueous sulfuric acid (6.5 g) was cooled to 0° to 5° C., and 60% nitric acid (0.8 g) was gradually added thereto at 0° to 5° C. The resultant mixture was stirred at the same temperature for 30 minutes and poured onto ice water. The precipitated crystals were collected by filtration, washed with water and dried to give 6-fluoro-5-nitro-2(3H)-benzoxazolone (1.1 g). m.p., 175.4° C.

後処理

  1. customat 0° to 5° C
  2. additionpoured onto ice water
  3. filtrationThe precipitated crystals were collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-dfbd4f56d62d4b44bc10e80a539b3cca
出典データセット
uspto-grants-1989_11
特許番号
US04880925

反応ノート

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