1-Pentanol → HCID 15696558、化合物

HRID 1639045

反応式

HRID 1639045 の反応式
[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1.[CH2:8](O)[CH2:9][CH2:10][CH2:11][CH3:12]>>[CH2:8]([O:1][CH:2]1[NH:6][C:5](=[O:7])[CH2:4][CH2:3]1)[CH2:9][CH2:10][CH2:11][CH3:12]

参加物

3

反応物 2

HCID 62761-PentanolHCID 1941485-Hydroxy-2-pyrrolidone

生成物 1

HCID 15696558HCID 15696558、化合物

実験手順

2.5 g of 5-hydroxy-pyrrolidin-2-one and 1.25 g of Amberlite IR 120H are heated to 65° C. for 3 hours in 55 cm3 of 1-pentanol. The resin is filtered off, and the remainder is distilled under reduced pressure at a temperature of 22° C./24° C. under 0.5 mbar. The residue is chromatographed on silica (eluent: ethyl acetate), and 2.68 g of the expected product is obtained. m.p. 42°-43° C.

後処理

  1. filtrationThe resin is filtered off
  2. distillationthe remainder is distilled under reduced pressure at a temperature of 22° C./24° C. under 0.5 mbar
  3. customThe residue is chromatographed on silica (eluent: ethyl acetate)

出典と根拠

ORDレコード
ord-2da8a7d65e384104a555b0c5607d181e
出典データセット
uspto-grants-1989_11
特許番号
US04882350

関連ノート

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