Kojic Acid → 5-(benzhydryloxy)-2-(hydroxymethyl)-4H-pyran-4-one

HRID 1639405ノート

反応式

HRID 1639405 の反応式
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9][OH:10].[C:11]1([C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N+]=[N-])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[CH:17]([O:8][C:5]1[C:6](=[O:7])[CH:1]=[C:2]([CH2:9][OH:10])[O:3][CH:4]=1)([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

4

反応物 2

HCID 3840Kojic AcidHCID 612301,1'-(Diazomethylene)bis(benzene)

生成物 1

HCID 143063875-(benzhydryloxy)-2-(hydroxymethyl)-4H-pyran-4-one収率 56.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
60 °C

実験手順

14.2 g (0.1 mol) of kojic acid was added to ethanol (400 ml), and heated to 60° C. and dissolved. After cooling the solution to room temperature, 29.1 g (0.15 mol) of diphenyldiazomethane was added thereto, and the mixture was reacted at room temperature for 18 hours under stirring. The reaction solution was concentrated to dryness, and benzene (300 ml) was added thereto. Then, insolubles were removed by filtration. To the filtrate, water (300 ml) was added, and the precipitates thereby formed were collected by filtration, and washed with benzene to obtain 17.5 g (yield: 56.8%) of the above identified compound.

後処理

  1. dissolutiondissolved
  2. temperatureAfter cooling the solution to room temperature
  3. customthe mixture was reacted at room temperature for 18 hours
  4. concentrationThe reaction solution was concentrated to dryness, and benzene (300 ml)
  5. additionwas added
  6. customThen, insolubles were removed by filtration
  7. additionTo the filtrate, water (300 ml) was added
  8. customthe precipitates
  9. customthereby formed
  10. filtrationwere collected by filtration
  11. washwashed with benzene
  12. customto obtain 17.5 g (yield: 56.8%) of the

出典と根拠

ORDレコード
ord-5b76433059b74213a1aa1ca94fa6bcda
出典データセット
uspto-grants-1989_11
特許番号
US04883879

反応ノート

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