Acetonitrile → HCID 1787923、化合物

反応式

[C:1]([O:5][CH3:6])(=[O:4])[NH:2][NH2:3].C(#N)C.[C:10]1([CH2:16][CH2:17][C:18](Cl)=[O:19])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([CH2:16][CH2:17][C:18]([NH:3][NH:2][C:1]([O:5][CH3:6])=[O:4])=[O:19])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

反応物 3

HCID 6342Acetonitrile

HCID 64801Benzenepropanoyl chloride

HCID 80519Methyl carbazate

生成物 1

HCID 1787923HCID 1787923、化合物収率 80.7%

実験手順

To a solution of 18 g. (0.2 moles) of methyl carbazate and 100 ml. of acetonitrile 33.7 g (0.2 moles) of β-phenylpropionyl chloride are added dropwise. The reaction mixture is heated to boiling for 15 hours, clarified and cooled. The crystals are filtered off. Thus 36.85 g of the desired compound are obtained, yield 80.7% m.p.: 118° C.