HCID 66722704、化合物 → Methyl 3-carbamoyl-4-hydroxybenzoate
反応式
C([O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][C:10]=1[C:19](=[O:21])[NH2:20])C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:19]([C:10]1[CH:11]=[C:12]([CH:17]=[CH:18][C:9]=1[OH:8])[C:13]([O:15][CH3:16])=[O:14])(=[O:21])[NH2:20]参加物
5
実験手順
Hydrogenolysis is effected by dissolving 1.2 gm (4.2 mmol) of methyl 4-benzyloxy-3-carbamoylbenzoate in 60 mL of methanol (warmed to effect solution), adding 1 gm of 10% Pd/C (50% water) catalyst, and stirring under 48 psi of hydrogen overnight at room temperature. The reaction mixture is filtered, and the catalyst is repeatedly washed with 10% MeOH/DCM. The combined filtrates are evaporated to dryness to give 0.79 gm (4.05 mmol, 96% yield) of methyl 3-carbamoyl-4-hydroxybenzoate.
後処理
- filtrationThe reaction mixture is filtered
- washthe catalyst is repeatedly washed with 10% MeOH/DCM
- customThe combined filtrates are evaporated to dryness
出典と根拠
- ORDレコード
- ord-5657a81bc4a645d7b86e8a8ae20acb10
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08110570B2
反応ノート
読み込み中…