Nitric Acid → 7-nitro-5H-pyrrolo[2,3-b]pyrazine

HRID 1639578

反応式

HRID 1639578 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[NH:7][CH:8]=[CH:9][C:2]=12.[N+:10]([O-])([OH:12])=[O:11].C(=O)(O)[O-].[Na+]>O>[N+:10]([C:9]1[C:2]2[C:3](=[N:4][CH:5]=[CH:6][N:1]=2)[NH:7][CH:8]=1)([O-:12])=[O:11]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 516892Sodium BicarbonateHCID 53708035H-Pyrrolo[2,3-b]pyrazine

生成物 1

HCID 122071927-nitro-5H-pyrrolo[2,3-b]pyrazine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

7-Nitro-5H-pyrrolo[2,3-b]pyrazine (5) is prepared by adding 5H-pyrrolo[2,3-b]pyrazine (3) to fuming nitric acid while cooling (e.g. 0° C.). After stirring for one to several hours, water is carefully added and the mixture neutralized with saturated sodium bicarbonate. The solids are collected by filtration and dried to provide 7-nitro-5H-pyrrolo[2,3-b]pyrazine 5.

後処理

  1. custom7-Nitro-5H-pyrrolo[2,3-b]pyrazine (5) is prepared
  2. additionis carefully added
  3. filtrationThe solids are collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-2f08133920194a08827817773bbfdaf3
出典データセット
uspto-grants-2012_02
特許番号
US08110576B2

関連ノート

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