Sodium Hydroxide → (2-Methylpyrazolo[1,5-a]pyridin-4-yl)methanol

HRID 1639743ノート

反応式

HRID 1639743 の反応式
[OH:1][CH2:2][C:3]1[C:4]2[N:5]([N:9]=[C:10]([CH3:17])[C:11]=2C(OCC)=O)[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[CH3:17][C:10]1[CH:11]=[C:4]2[C:3]([CH2:2][OH:1])=[CH:8][CH:7]=[CH:6][N:5]2[N:9]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59334472Ethyl 4-(hydroxymethyl)-2-methylpyrazolo[1,5-a]pyridine-3-carboxylate

生成物 1

HCID 59334539(2-Methylpyrazolo[1,5-a]pyridin-4-yl)methanol収率 99%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
100 °C

実験手順

A mixture of ethyl 4-(hydroxymethyl)-2-methylpyrazolo[1,5-a]pyridine-3-carboxylate (41.0 g, 0.180 mol) and 40% aqueous sulfuric acid solution (350 mL) was stirred at 100° C. for 2 hr. The reaction mixture was basified with 10% aqueous sodium hydroxide solution, and extracted with dichloromethane. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give the title compound (28.0 g, yield 99%).

後処理

  1. extractionextracted with dichloromethane
  2. dry with materialThe extract was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-34668994e19f439cace307091e02eaa3
出典データセット
uspto-grants-2012_02
特許番号
US08110585B2

反応ノート

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