Hydrazine hydrate (1:1) → cis-1-[2-(2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine

HRID 1639768ノート

反応式

HRID 1639768 の反応式
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C@H:11]2[CH2:13][C@H:12]2[CH2:14][N:15]2C(=O)C3C(=CC=CC=3)C2=O)=[N:3]1.O.NN>C(O)C>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C@H:11]2[CH2:13][C@H:12]2[CH2:14][NH2:15])=[N:3]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 66720712HCID 66720712、化合物

生成物 1

HCID 66720689cis-1-[2-(2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A crudely purified product of cis-2-{[2-(2-methyl-2H-indazol-4-yl)cyclopropyl]methyl}-1H-isoindole-1,3(2H)-dione was dissolved in ethanol (6.5 mL), and hydrazine monohydrate (3 mL) was added. The mixture was heated under reflux for 20 min. The solvent was evaporated under reduced pressure. Saturated aqueous sodium hydrogen carbonate solution was added to the residue, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give the title compound as a crudely purified product.

後処理

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 20 min
  3. customThe solvent was evaporated under reduced pressure
  4. additionSaturated aqueous sodium hydrogen carbonate solution was added to the residue
  5. extractionthe mixture was extracted with ethyl acetate
  6. dry with materialThe extract was dried over anhydrous sodium sulfate
  7. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-f66e6b321fc1401fad3f65b85370967c
出典データセット
uspto-grants-2012_02
特許番号
US08110585B2

反応ノート

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