Water → (Indolin-3-yl)methanol
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([C:10](OCC)=[O:11])[CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C1COCC1.O>C1COCC1>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([CH2:10][OH:11])[CH2:2]1参加物
5
実験手順
0.79 g (3.5 mmol) ethyl 2,3-dihydro-1H-indole-3-carboxylate were added batchwise at RT to 7.8 mL (7.8 mmol) of a 1 molar lithium aluminium hydride-THF solution in 40 mL THF and the mixture was refluxed for 1 h. Then the reaction mixture was decomposed with water, while cooling, the precipitate formed was filtered off and the filtrate was evaporated down.
後処理
- temperaturethe mixture was refluxed for 1 h
- temperaturewhile cooling
- customthe precipitate formed
- filtrationwas filtered off
- customthe filtrate was evaporated down
出典と根拠
- ORDレコード
- ord-c524079a8a074415854c0622f1d88425
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08110575B2
反応ノート
読み込み中…