Diisopropylethylamine → 1-(6-(indoline-1-carbonyl)pyrimidin-4-yl)spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

HRID 1640266ノート

反応式

HRID 1640266 の反応式
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]2([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:2]1=[O:15].Cl[C:17]1[N:22]=[CH:21][N:20]=[C:19]([C:23]([N:25]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:27][CH2:26]2)=[O:24])[CH:18]=1.CCN(C(C)C)C(C)C>CN(C=O)C>[N:25]1([C:23]([C:19]2[N:20]=[CH:21][N:22]=[C:17]([N:12]3[CH2:11][CH2:10][C:3]4([C:4]5[C:5](=[N:6][CH:7]=[CH:8][CH:9]=5)[NH:1][C:2]4=[O:15])[CH2:14][CH2:13]3)[CH:18]=2)=[O:24])[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH2:26]1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 56651734Spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-oneHCID 58117518(6-Chloropyrimidin-4-yl)-(2,3-dihydroindol-1-yl)-methanone

生成物 1

HCID 426100731-(6-(indoline-1-carbonyl)pyrimidin-4-yl)spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

43 mg (0.21 mmol) spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one were added to 50 mg (0.19 mmol) (6-chloro-pyrimidin-4-yl)-(2,3-dihydro-indol-1-yl)-methanone and 52 μL (0.58 mmol) DIPEA in 5 mL DMF. The reaction mixture was stirred for 2 h at RT. The reaction mixture was evaporated down using the rotary evaporator and the residue was mixed with 20 mL water and stirred for 30 min at RT. The product precipitated was suction filtered, stirred with diisopropylether and isopropanol, suction filtered and dried.

後処理

  1. customThe reaction mixture was evaporated down
  2. customthe rotary evaporator
  3. additionthe residue was mixed with 20 mL water
  4. stirringstirred for 30 min at RT
  5. customThe product precipitated
  6. filtrationfiltered
  7. stirringstirred with diisopropylether and isopropanol, suction
  8. filtrationfiltered
  9. customdried

出典と根拠

ORDレコード
ord-0c73855477984bb493bcf676f4b1cebe
出典データセット
uspto-grants-2012_02
特許番号
US08110575B2

反応ノート

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