Imidazole → Tert-butyl-hex-5-enyloxy-dimethyl-silane
反応式
[CH2:1]([OH:7])[CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6].[CH3:8][C:9]([Si:12](Cl)([CH3:14])[CH3:13])([CH3:11])[CH3:10].N1C=CN=C1.O>C1COCC1>[C:9]([Si:12]([O:7][CH2:1][CH2:2][CH2:3][CH2:4][CH:5]=[CH2:6])([CH3:14])[CH3:13])([CH3:11])([CH3:10])[CH3:8]参加物
6
実験手順
To a solution of 5-hexen-1-ol (5 g, 50 mmol) in THF (80 mL) were sequentially added TBDMSCl (8.4 g, 55 mmol) and imidazole (4.01 g, 60 mmol). The mixture was stirred at rt overnight. Water was added and the two phases separated. The aq. phase was extracted with ether and the combined org. layers were dried over MgSO4 and concentrated to give the title intermediate as a colourless liquid (11.2 g, 100% yield).
後処理
- customthe two phases separated
- extractionThe aq. phase was extracted with ether
- dry with materiallayers were dried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-275f0dbd67ea4aeaab698bfe230a815f
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08114867B2
反応ノート
読み込み中…