Hydrochloric Acid → 5-Methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylic acid

反応式

[OH-].[Na+].[CH3:3][C:4]1[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=2)[C:6](=[O:14])[C:7]([C:10]([O:12]C)=[O:11])=[N:8][CH:9]=1.Cl>CCO>[CH3:3][C:4]1[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:22])[F:23])[CH:16]=2)[C:6](=[O:14])[C:7]([C:10]([OH:12])=[O:11])=[N:8][CH:9]=1

参加物

実験手順

NaOH (1M, 6 ml) was added to methyl 5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxylate (0.60 g, 1.92 mmol) dissolved in EtOH (12 ml) and the to mixture was stirred for 15 minutes. The aqueous phase was neutralized by addition of HCl (1M, 7 ml) to pH 6 to 7 and extracted with ethyl acetate (3×15 ml). The organic phase was dried (MgSO4), filtered and evaporated. No further purification was performed.