Trifluoroacetic acid → 6-Fluoro-4-iodopyridin-3-amine
反応式
[F:1][C:2]1[N:7]=[CH:6][C:5]([NH:8]C(=O)OC(C)(C)C)=[C:4]([I:16])[CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[F:1][C:2]1[N:7]=[CH:6][C:5]([NH2:8])=[C:4]([I:16])[CH:3]=1参加物
4
実験手順
Dissolve tert-butyl 6-fluoro-4-iodopyridin-3-ylcarbamate (1.47 g, 4.35 mmol) in DCM (20 mL). Add trifluoroacetic acid (TFA) (20 mL). Stir at RT under N2 for 2 h. Remove the solvent under reduced pressure. Dry in vacuo to afford 6-fluoro-4-iodopyridin-3-amine in TFA salt (1.02 g, 99%) with 100% HPLC purity. MS (ES) m/z 239 [M+1]+.
後処理
- customRemove the solvent under reduced pressure
- customDry in vacuo
出典と根拠
- ORDレコード
- ord-7d6d42959755413888c1db4b09f02e88
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08114872B2
反応ノート
読み込み中…