Sulfuric Acid → 1H-indazol-4-ol

HRID 16411

反応式

HRID 16411 の反応式
[NH:1]1[C:9]2[C:4](=[C:5](N)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.S(=O)(=O)(O)[OH:12].[OH-].[Na+]>>[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([OH:12])[C:4]=2[CH:3]=[N:2]1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 413085NoName_3327

生成物 1

HCID 1357424501H-indazol-4-ol

実験手順

500 mg (375 mmol) of 1H-indazol-4-ylamine (prepared according to J. Chem. Soc. 1955, 2412, 2419) are stirred in 10% strength sulfuric acid at 180° C. in an autoclave at intrinsic pressure overnight. The reaction solution is cooled to room temperature and neutralized with 1N sodium hydroxide solution, and the salts are filtered off. The filtrate is concentrated to dryness.

後処理

  1. filtrationthe salts are filtered off
  2. concentrationThe filtrate is concentrated to dryness

出典と根拠

ORDレコード
ord-3424705caf554a55a61da2572693309a
出典データセット
uspto-grants-2010_06
特許番号
US07737153B2

関連ノート

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