2-Methylindanone → Methylindan-1-one oxime

HRID 1641377

反応式

HRID 1641377 の反応式
[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=O.Cl.[NH2:13][OH:14].C([O-])(=O)C.[Na+]>C(O)C.O>[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[N:13][OH:14]

参加物

6

反応物 3

HCID 2492622-MethylindanoneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

生成物 1

HCID 73454082Methylindan-1-one oxime収率 89.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

A mixture of 2-methyl-1-indanone (10 g, 0.0684 mol) and hydroxylamine hydrochloride (9.5 g, 0.1368 mol) in ethanol was stirred at 60° C., and a solution of sodium acetate (16.8 g, 0.2052 mol) in water added. The resulting mixture was then heated at reflux for 90 minutes, then cooled and the solid filtered. The crude product was washed with water and filtered to give 2-methyl-indan-1-one oxime (9.9 g, yield 81%), mp. 82-91° C., in 90% purity.

後処理

  1. temperatureThe resulting mixture was then heated
  2. temperatureat reflux for 90 minutes
  3. temperaturecooled
  4. filtrationthe solid filtered
  5. washThe crude product was washed with water
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-bc3dafd1fd074be09964f9c4bf057cae
出典データセット
uspto-grants-2012_02
特許番号
US08114991B2

関連ノート

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