(3'R)-1'-(Phenylmethyl)-1,3'-bipyrrolidine → (3R)-3-(Pyrrolidin-1-YL)pyrrolidine

HRID 1641899ノート

反応式

HRID 1641899 の反応式
C([N:8]1[CH2:12][CH2:11][C@@H:10]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[N:13]1([C@@H:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH2:17][CH2:16][CH2:15][CH2:14]1

参加物

4

反応物 1

HCID 66629680(3'R)-1'-(Phenylmethyl)-1,3'-bipyrrolidine

生成物 1

HCID 7176272(3R)-3-(Pyrrolidin-1-YL)pyrrolidine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A solution of (R)-1′-benzyl-[1,3′]bipyrrolidinyl (0.517 g, 2.24 mmol) in methanol (25 ml) under an atmosphere of argon is treated with palladium hydroxide on carbon (0.1 g). The reaction mixture is placed under an atmosphere of hydrogen, stirred at room temperature overnight and then filtered through Celite™ filter material. The filtrate is concentrated in vacuo to yield the title compound as a dark orange oil.

後処理

  1. filtrationfiltered through Celite™
  2. filtrationfilter material
  3. concentrationThe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-6a9e0c8e1b69458293c4bc6d6043da63
出典データセット
uspto-grants-2012_02
特許番号
US08114877B2

反応ノート

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