Piperidine → Piperidine, 1-(1-cyclopenten-1-yl)-

HRID 1642040ノート

反応式

HRID 1642040 の反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:7]1(=O)[CH2:11][CH2:10][CH2:9][CH2:8]1>C1C=CC=CC=1>[C:7]1([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH2:11][CH2:10][CH2:9][CH:8]=1

参加物

4

反応物 2

HCID 8082PiperidineHCID 8452Cyclopentanone

生成物 1

HCID 137114Piperidine, 1-(1-cyclopenten-1-yl)-

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
80 °C

実験手順

Piperidine (4.0 g, 46.9 8 mmol) was added to a solution of cyclopentanone Compound 1a (4.0 g, 46.50 mmol) in benzene (100 mL) at ambient temperature under a N2 atmosphere. The mixture was refluxed at 80° C. for 5 hrs using a Dean Stark apparatus, then concentrated to dryness to provide 1-cyclopent-1-enyl-piperidine Compound 1b (7.0 g) as a crude oil which was used in the next step without further purification.

後処理

  1. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-f0eb7fbd049a4d46ab034025e7f80f8d
出典データセット
uspto-grants-2012_02
特許番号
US08119621B2

反応ノート

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