Diethyl 2-nitrobenzylphosphonate → Diethyl [(2-aminophenyl)methyl]phosphonate

HRID 1642061ノート

反応式

HRID 1642061 の反応式
[CH2:1]([O:3][P:4]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-])=O)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]>C(O)C.[Pd]>[CH2:6]([O:5][P:4]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:16])(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

参加物

4

反応物 1

HCID 11277310Diethyl 2-nitrobenzylphosphonate

生成物 1

HCID 13649220Diethyl [(2-aminophenyl)methyl]phosphonate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1.13 g of (2-nitro-benzyl)-phosphonic acid diethyl ester) in ethanol are hydrogenated with Pd—C as a catalyst for 5 hours at rt and ambient pressure. The catalyst is removed by filtration and from the filtrate obtained solvent is evaporated. (2-Amino-benzyl)-phosphonic acid diethyl ester is obtained.

後処理

  1. customThe catalyst is removed by filtration and from the filtrate
  2. customobtained solvent
  3. customis evaporated

出典と根拠

ORDレコード
ord-73e903e834f1447281705517e2b27da9
出典データセット
uspto-grants-2012_02
特許番号
US08119617B2

反応ノート

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