Sodium Hydroxide → HCID 178507499、化合物

HRID 1642334ノート

反応式

HRID 1642334 の反応式
C([O:4][C:5]([C:7]1[O:14][C:13]2[C:12]([NH:15][C:16](=[O:26])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N+:23]([O-])=O)=[N:11][N:10](C(OCC)=O)[C:9]=2[CH:8]=1)=[O:6])CC.[OH-].[Na+]>CO>[NH2:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:16]([NH:15][C:12]1[NH:11][N:10]=[C:9]2[CH:8]=[C:7]([C:5]([OH:6])=[O:4])[O:14][C:13]=12)=[O:26]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 578786493-(2-Nitro-benzoylamino)-furo[3,2-c]pyrazole-1,5-dicarboxylic acid 1-ethyl ester 5-propyl ester

生成物 1

HCID 178507499HCID 178507499、化合物収率 129%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 3-(2-Nitro-benzoylamino)-furo[3,2-c]pyrazole-1,5-dicarboxylic acid 1-ethyl ester 5-propyl ester (7.6 g, 0.0176 mol) in methanol (100 mL), NaOH 2N (44.1 mL, 0.0882 mmol) was added. The mixture was gently refluxed for 8 hours, then the solvent was evaporated under vacuum, and the residual aqueous solution was diluted with water and ice. Hydrochloric acid (12 N) was added until pH 2. The yellowish solid that precipitated was collected, washed with water and dried under vacuum at 60° C. 6.5 g of the title compound was so obtained.

後処理

  1. temperatureThe mixture was gently refluxed for 8 hours
  2. customthe solvent was evaporated under vacuum
  3. additionthe residual aqueous solution was diluted with water and ice
  4. additionHydrochloric acid (12 N) was added until pH 2
  5. customThe yellowish solid that precipitated was collected
  6. washwashed with water
  7. customdried under vacuum at 60° C

出典と根拠

ORDレコード
ord-4643ff21cfc143c085204e3c795e16b7
出典データセット
uspto-grants-2012_02
特許番号
US08119641B2

反応ノート

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