Iodine → 6-Iodo-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

HRID 1642374ノート

反応式

HRID 1642374 の反応式
CC1N=C2SC=CN2C(=O)C=1.II.ClC1C=CC(/C=[CH:22]/[C:23]2[N:24]=[C:25]3[S:33][CH:32]=[CH:31][N:26]3[C:27](=[O:30])[C:28]=2[I:29])=CC=1>C(#N)C>[I:29][C:28]1[C:27](=[O:30])[N:26]2[CH:31]=[CH:32][S:33][C:25]2=[N:24][C:23]=1[CH3:22]

参加物

5

反応物 3

HCID 807IodineHCID 5970657-Methyl-5H-(1,3)thiazolo(3,2-a)pyrimidin-5-oneHCID 66753972HCID 66753972、化合物

生成物 1

HCID 667535716-Iodo-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A stirred solution of Step 1 Intermediate (20 g, 120.463 mmol) in acetonitrile (200 ml) was treated with ceric ammonium nitrate (33 g, 60.233 mmol) and iodine (18 g, 72.281 mmol) at room temperature according to the procedure outlined in Intermediate 1, Step 3 to give 35 g of the product as a light yellow solid; 1H NMR (300 MHz, DMSO-d6) δ 2.56 (s, 3H), 7.52 (d, J=5.1 Hz, 1H), 7.97 (d, J=4.8 Hz, 1H); ESI-MS (m/z) 291.29 (M−H)−.

出典と根拠

ORDレコード
ord-ed55976fa2264f37944e536d84f6d7b5
出典データセット
uspto-grants-2012_02
特許番号
US08119647B2

反応ノート

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