Sodium Carbonate → 6-(3,5-Difluorophenyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

HRID 1642375ノート

反応式

HRID 1642375 の反応式
I[C:2]1[C:7](=[O:8])[N:6]2[CH:9]=[CH:10][S:11][C:5]2=[N:4][C:3]=1[CH3:12].C([O-])([O-])=O.[Na+].[Na+].[F:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[C:24]([F:26])[CH:25]=1>C1(C)C=CC=CC=1.O.C(O)C>[F:19][C:20]1[CH:21]=[C:22]([C:2]2[C:7](=[O:8])[N:6]3[CH:9]=[CH:10][S:11][C:5]3=[N:4][C:3]=2[CH3:12])[CH:23]=[C:24]([F:26])[CH:25]=1

参加物

7

反応物 3

HCID 10340Sodium CarbonateHCID 2734338(3,5-Difluorophenyl)boronic acidHCID 667535716-Iodo-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

生成物 1

HCID 667534716-(3,5-Difluorophenyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

To a solution of Step 2 intermediate (0.300 g, 1.027 mmol) in toluene (10 ml) was added Pd[(C6H5)3P]4 [tetrakis(triphenylphosphine)palladium(0)] (0.048 g. 0.042 mmol) and a solution of Na2CO3 (0.653 g, 6.162 mmol) in water (4 ml). A solution of 3,5-difluorophenylboronic acid (6.5 g, 44.235 mmol) in ethanol (6 ml) was added to the reaction mixture and it was refluxed for 1.5 h. After completion of the reaction mixture, the solvent was concentrated in vacuo, the residue partitioned between ethyl acetate (200 ml) and water (50 ml). The organic layer was washed with brine (50 ml) and dried over anhydrous Na2SO4 to afford a crude product which was purified by silica gel column chromatography using 10% ethyl acetate in chloroform to give 280 mg of the product as an off-white solid; 1H NMR (300 MHz, DMSO-d6) δ 2.19 (s, 3H), 7.53 (d, J=7.8 Hz, 3H), 7.88 (d, J=7.8 Hz, 1H) 8.02 (d, J=4.8 Hz, 1H); ESI-MS (m/z) 276.31 (M−H)−.

後処理

  1. temperaturewas refluxed for 1.5 h
  2. concentrationAfter completion of the reaction mixture, the solvent was concentrated in vacuo
  3. customthe residue partitioned between ethyl acetate (200 ml) and water (50 ml)
  4. washThe organic layer was washed with brine (50 ml)
  5. dry with materialdried over anhydrous Na2SO4
  6. customto afford a crude product which
  7. customwas purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-cec5e7466f4a4532b7d1d4692e5d3704
出典データセット
uspto-grants-2012_02
特許番号
US08119647B2

反応ノート

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