Iodine → 6-Iodo-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

HRID 1642377ノート

反応式

HRID 1642377 の反応式
II.ClC1C=CC(/C=[CH:11]/[C:12]2[N:13]=[C:14]3[S:22][CH:21]=[CH:20][N:15]3[C:16](=[O:19])[C:17]=2[I:18])=CC=1>C(#N)C>[I:18][C:17]1[C:16](=[O:19])[N:15]2[CH:20]=[CH:21][S:22][C:14]2=[N:13][C:12]=1[CH3:11]

参加物

4

反応物 2

HCID 807IodineHCID 66753972HCID 66753972、化合物

生成物 1

HCID 667535716-Iodo-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A stirred solution of the Step 1 intermediate (20 g, 120.463 mmol) in acetonitrile (200 ml) was reacted with ceric ammonium nitrate (33 g, 60.233 mmol) followed by iodine (18 g, 72.281 mmol) according to the procedure described in Intermediate 1, Step 3 to give 35 g of the product as a light yellow solid; 1H NMR (300 MHz, DMSO-d6) δ 2.56 (s, 3H), 7.52 (d, J=5.1 Hz, 1H), 7.97 (d, J=4.8 Hz, 1H); ESI-MS (m/z) 291.29 (M−H)−.

出典と根拠

ORDレコード
ord-f7b78c2b2502407f81e80b5b80372fe7
出典データセット
uspto-grants-2012_02
特許番号
US08119647B2

反応ノート

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