Hydrochloric Acid → 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile

HRID 16425

反応式

HRID 16425 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH2:10][C:11]1[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=1.Cl>O>[NH2:1][C:2]1[N:3]=[C:4]([NH:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)[CH:5]=[C:6]([Cl:8])[N:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 133964-AminobenzonitrileHCID 655222-Amino-4,6-dichloropyrimidine

生成物 1

HCID 2408064-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

300 mg (1.83 mmol) of 2-amino-4,6-dichloropyrimidine and 216 mg (1.83 mmol) of 4-aminobenzonitrile are suspended in 6 ml of water. 180 μl of concentrated hydrochloric acid are added, and the mixture is stirred at 100° C. overnight. The precipitate is filtered off with suction.

後処理

  1. filtrationThe precipitate is filtered off with suction

出典と根拠

ORDレコード
ord-b294971d5690468ca48fed2a90495ae2
出典データセット
uspto-grants-2010_06
特許番号
US07737153B2

関連ノート

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